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Unlike BVO, the etiologic diag-nosis of TVO requires a vertebral biopsy in a high percentage of cases. Theauthor may cite—and attempt to document—the inadequacy of previous research in thearea under investigation. (1983)The ear effect as a function of age and hearing loss. The leukocyte count in the synovial fluid was 15,000 cells/µl, of which 67%were neutrophils The leukocyte count in the synovial fluid was 15,000 cells/µl, of which 67%were neutrophils. This male preponder-ance has also been observed in other studies going from 60%  up to 86% .
The growingevidence surrounding the Mdm2-MdmX-p53 triumvirate suggests a complexrelationship between these proteins that modi?es their functions, modi? cations, andstabilities [ 62]. Raynaud’s phenomenonmay occur just before or with skin symptoms. Dopamineantagonists such as bromocriptine and tumor necrosisfactor (TNF) inhibitors such as etanercept also may causeheadache. It should be administered in empty stomachto avoid interference by food.
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Itsinclusion has enabled duration of treatment tobe shortened and risk of relapse to be reduced.The mechanism of action of Z is not wellestablished, but like INH it is also convertedinside the mycobacterial cell into an activemetabolite pyrazinoic acid by an enzyme(pyrazinamidase) encoded by the pncA gene.
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